The cecum from TLR4−/− and MyD88−/− had marked inflammatory cell infiltrates with oedema and epithelial disruption on days 3 and 7 post infection, that was significantly (p<0.05−0.01) greater than the mild inflammation in the cecum of infected wild-type, TLR2−/− or TRIF−/− mice (Figure 8C, 8D). Here, TLR4 is linked to infection.