FOXE3 and congenital primary aphakia: We found no cases of CCO associated with aberrations in 1p32, which is the locus harboring FOXE3. This gene is a forkhead transcription factor that has been implicated in early lens and anterior segment formation, mutations of which have been found in dominantly inherited ASDA and cataract, as well as in recessive primary congenital aphakia with secondary anterior segment dysgenesis [6,7,67].