PCLAF and Multiple Organ Failure: It seems that these newly found anti-inflammatory and anti-thrombotic properties of antibiotics and/or antibiotic regimens used in sepsis, such as their inhibitory activities towards PAF/PAFR and thrombin pathways, as well as their interactions with PAF-metabolism, may provide new perspectives for these drugs towards also the inflammatory and coagulant manifestations that usually take place during several septic stages, including induced by severe sepsis multiple organ failure.