It seems that these newly found anti-inflammatory and anti-thrombotic properties of antibiotics and/or antibiotic regimens used in sepsis, such as their inhibitory activities towards PAF/PAFR and thrombin pathways, as well as their interactions with PAF-metabolism, may provide new perspectives for these drugs towards also the inflammatory and coagulant manifestations that usually take place during several septic stages, including induced by severe sepsis multiple organ failure. This evidence concerns the gene PCLAF and Sepsis.