However, more in vitro and in vivo tests in animal models are needed in order to confirm which of the antibiotic regimens used in sepsis may exhibit the most potent anti-inflammatory effect through the highest in vivo inhibitory effect against PAF activities and biosynthesis, with simultaneously induction of PAF-degradation, in an effort to increase our understanding of the clinical implications of PAF inhibition with regard to septic shock, severe sepsis and induced multiple organ failure. This evidence concerns the gene PCLAF and septic shock.