Using the RCAS/TV-A system [24] we established mouse glioma cell lines, derived from PDGFB induced tumors, in Ntv-a (the avian TVA receptor for RCAS virus driven by Nestin promoter) transgenic mice with wild type, Ink4A-/- or Arf-/- genetic backgrounds. This evidence concerns the gene CDKN2A and central nervous system cancer.