IT anti-c-Met/PE38KDEL (anti-c-Met Fab, which resulted from screening and characterization from a natural human Fab phage antibody library; PE38KDEL, which is a modified structure of PE38, lost the function of combining with non-mammalian cells specifically, but retained a complete cytotoxicity after internalization) has shown specific cytotoxic effects against c-Met-positive cancer cells [10]. Here, MET is linked to cancer.