While the alkaline ceramidase and Per1 were proposed to possess hydrolase activities in ceramide or GPI-anchored protein biosynthesis pathways, it is quite interesting how such putative hydrolase activity contributes to the diverse and seemingly unrelated functions of hormone receptors, bacterial hemolysins, the SID1 dsRNA transporters and the TMEM8 putative tumor suppressers. Here, PER1 is linked to neoplasm.