In the study presented herein we have observed high tumor expression of FGF2 and the co-expressions of FGF2 & PDGF-B and FGF2 & VEGFR-3 to be significant, independent and unfavorable prognostic indicators of DSS in non-GIST STS patients with wide resection margins. This evidence concerns the gene FLT4 and gastrointestinal stromal tumor.