PLOD1 and polycystic ovary syndrome: Due to the hypersecretion of LH in some patients with PCOS, gonadotrophin preparations containing only FSH activity were considered to have theoretical advantages over human menopausal gonadotrophin (hMG) preparations which contain both FSH and LH activity (Hillier, 1994; Shoham, 2002; Balasch, 2004).