STAT3 and cancer: Recent evidences suggest the anti-cancer effects of BA [7], [8], anti-inflammatory [9] and anti-viral [10] activities via various signaling pathways such as epidermal growth factor receptor (EGFR) [11], hedgehog [12], signal transducer and activator of transcription 3 (STAT3) [13] and nuclear factor-kappa B (NF-κB) [14].