Infection with live CP, but not UVCP treatment, resulted in a significant decrease in ΔΨm (Figure 7A) as measured by a tetramethyl rhodamine methyl ester (TMRM) incorporation assay in BMDM, implicating a potential role of the mitochondria in NLRP3 inflammasome activation and IL-1β release. The gene discussed is NLRP3; the disease is infection.