Moreover, leptin induces VEGF/VEGFR-2 expression, angiogenesis and growth of human ovary cancer xenografts in nude mice and in 7,12- dimethylbenz[a]anthracene (DMBA)-diet-induced-obesity (DIO) mouse models of breast cancer (Gonzalez-Perez, Manuscript in preparation). The gene discussed is LEP; the disease is ovarian cancer.