HUS patients often exhibit a systemic cytokine response with increased serum concentrations of pro-inflammatory cytokines such as interleukin (IL)-8, IL-1β, IL-6 and, in some cases, tissue necrosis factor α (TNFα), as well as a decline in anti-inflammatory cytokines [13], [14], [15], [16], [17], [18]. This evidence concerns the gene TNF and hemolytic-uremic syndrome.