Using mice with a deletion of the HRE of the VEGF promoter, which renders them incapable of up-regulating VEGF in response to HIF, there was almost a total inhibition of retinal NV and vascular leakage due to BRB breakdown in a model of OIR and of CNV in a model of AMD [11], showing that these activities are mediated through HIF-induced VEGF in these models. The gene discussed is VEGFA; the disease is age-related macular degeneration.