Manipulating the signaling molecules or pathways that regulate stabilization of vasculatures and/or normalization of NV, such as Dll4/Notch signaling, which prevents tip cell formation and branching and was shown to normalize neo vessels in cancer [66], or master transcription factors, such as HIF1α, which controls the expression of VEGF and other genes that regulate vascular biology, metabolism, angiogenesis, proliferation, and survival, would be possible treatment options [67]. The gene discussed is DLL4; the disease is cancer.