FLT1 and cancer: Previous reports have demonstrated that both VEGFR1 and 2 play very important roles in mediating adverse complications of ischemic and inflammatory disorders, particularly in cancers [25]–[28], and our present study gave further insight into their respective roles and mechanisms in pathological angiogenesis and vascular leakage with the two widely-used mouse models of ocular angiogenesis: laser-induced CNV and OIR.