However, APP [23]-[27], Presenilin1/2 [28], [29], tau [30], [31], Apolipoprotein E [32], Cdk5 [33], TDP-43 [34] or GSK-3beta [35], which are implicated in Alzheimer's disease and tauopathy, were not included in these results. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.