Although MPO+ neutrophils could be regularly found in livers from CLD patients by immunohistochemistry, the clear increase of IL-8 and CXCR1 mRNA in cirrhotic samples was not associated with increased neutrophil counts in livers with cirrhosis compared to non-cirrhotic livers (Fig. 3A). Here, MPO is linked to congenital secretory chloride diarrhea 1.