In addition to the experimental alterations in TIN2 protein levels, which clearly demonstrate that TIN2 level changes can disrupt telomere end structure and result in cell distress and/or death, several studies have shown that the changes in the endogenous expression level of several telomere-binding proteins (including TIN2) may be associated with various forms of human cancer [20], [21], [22], [23], [24]. This evidence concerns the gene TINF2 and cancer.