We checked the transcriptome data for NR2F binding factors expression (HNF4A, HNF4G, NR2C, NR2F) and for KLFS binding factors (KLF proteins), and could show that KLF4, 5, 7 are expressed at an intermediate level in the liver and are down-regulated 2 to 3 fold by IUGR, suggesting that a decrease level of specific KLFs could participate in the reduced expression level of down-regulated genes. Here, KLF4 is linked to fetal growth restriction.