In accordance with a recent study that showed robust induction of IP-10, RANTES, and IL-6 production following infection with HPAI H5N1 in alveolar epithelial cells [64], we show in this study that fully differentiated NHBE cells infected with LPAI H5N1, H5N2 and H5N3 induce robust IP-10 and RANTES responses early during infection compared to human H3N2 infection. The gene discussed is CXCL10; the disease is infection.