Despite differences in molecular characteristics between cells in vivo and in vitro, our approach allowed us to identify 4 genes, the expression of which is likely mediated by ERBB2. We highlight LOX downregulation in C5.2 cells as well as in tumor samples overexpressing ERBB2. Furthermore, our data also revealed a higher level of LOX expression in C5.2 cells after exposure to rapamycin (4-fold change), data indicating that LOX is potentially regulated by the ERBB2/mTOR pathway. Here, LOX is linked to neoplasm.