The presence of microRNA1 as a differentially regulated hub in MAM-treated animals is noteworthy because of its ability to regulate insulin signaling (especially the IGF-1 receptor) [49], its association with colon cancer [50], and the key roles of ERK1 and microRNAs in tau phosphorylation and AD [51]. This evidence concerns the gene MAPK3 and malignant colon neoplasm.