Furthermore, our study points at an important role of IRF8 in transcriptional activation of several families of IFN-inducible intracellular GTPases of the p47 (IRG), p65 (GBPs) and Dynamin (Mx) families which are known to be essential for protection against intracellular bacterial, parasitic and viral infections (Figure 4C) [40]. This evidence concerns the gene IRF8 and viral infectious disease.