To identify IRF8 targets that may play an important role in host defenses against pulmonary tuberculosis, we investigated which of the 319 IRF8 binding sites and associated genes are significantly regulated in the lungs of C57BL6/J (B6) mice 30 days following aerosol infection with M. tuberculosis (pairwise analysis of day 30 versus day 0 transcript profiles) [29]. The gene discussed is IRF8; the disease is infection.