The glial cell-specific driver repo-Gal4 was used to suppress polymerase expression in fly BBB cells through in vivo shRNA knockdown of ttv, sotv, and botv. After infection with WT GBS A909, flies with glial cell-specific knockdown of either botv alone, or both ttv and sotv displayed higher survival rates than the corresponding repo and Gal4-UAS controls (Figure 1 C and D). This evidence concerns the gene EXTL3 and infection.