EPCAM and carcinoma: This could be due to the interaction of the cell surface glycoprotein (extracellular domain) with intracellular cytoskeletal domain for cell adhesion.[7] Studies have also shown that any deletion in this cytoplasmic domain of EGP40 (Ep-CAM) molecule may result in weak or unstable adhesions and a decrease in cell aggregation[2] which may promote invasion and metastasis from the carcinoma or from the primary tumor.[5]