ACHE and dementia: Twenty-nine percent of persons were receiving a medication that was classified as never appropriate, including HMG-CoA (3-hydroxy-3-methyl-glutaryl coenzyme A) reductase inhibitors (statins), acetylcholinesterase inhibitors, estrogen, and clopidogrel, and 21% were receiving medication that were rarely appropriate.21 Blass et al.18 examined medication use among nursing home residents with advanced dementia (n = 125), in particular how medication use changed as death approached.