BCL2 and breast carcinoma: Our result is consistent with a number of studies which show that drugs like flavopiridol, lipoxygenase inhibitors and roscovitine downregulated both Mcl-1 and Bcl-2 in breast cancer cells, while okadaic acid and immunotoxins among others specifically downregulated only Mcl-1 to induce apoptosis (Rieber et al, 2002; Tong et al, 2002; Wittmann et al, 2003; Andersson et al, 2004; Ortiz-Ferrón et al, 2008).