We therefore investigated the effect of NU6027 on cell cycle arrest and cytotoxicity of these agents in human ovarian cancer cells with differing MMR and p53 status; A2780 (MMR+ and p53+), CP70-B1 (MMR+, p53–) and CP70-A2 (MMR–, p53–) (Figure 4). The gene discussed is MRC1; the disease is ovarian carcinoma.