Signal transducer and activator of transcription 3 activation by various receptor tyrosine kinases has previously been shown to be JAK dependent or JAK independent (Olayioye et al, 1999; Paukku et al, 2000; Ren and Schaefer, 2002; Bong et al, 2007); however, it is unclear whether STAT3 is phosphorylated through JAK in MET-activated gastric cancer cell lines. Here, STAT3 is linked to gastric cancer.