The Oct4-TN that we described provides a useful resource to 1) further study the mechanisms of Oct4 function and regulation during the maternal-to-embryo transition; 2) explore the link between the regulation of pluripotency and the acquisition of dedifferentiation in cancer cells; 3) improve our understanding of the molecular factors that contribute to the mammalian egg developmental competence and give opportunities for testing new prognostic molecular markers of oocyte quality in animal and human assisted reproduction. This evidence concerns the gene POU5F1 and cancer.