The presence of lymph node metastases, however, correlated with increased levels of several CAC such as VEGF (p = 0.02), VEGFR-1 (p = 0.006), PDGF-AA (p = 0.04), PDGF-BB (p = 0.0008), Ang-1 (p = 0.004) and EGF (p = 0.03). This evidence concerns the gene FLT1 and metastatic malignant neoplasm in the lymph nodes.