Major pathway differences related to a survival advantage for HCC can also be observed at the intracellular level: a closer look into the insulin pathway shows that INS→ IRβ and INS→ IGFR edges are removed in hepatocytes but the INS→ IRβ is retained in Huh7 (star#5, Figure 3). The gene discussed is INS; the disease is hepatocellular carcinoma.