Since it has been reported that the expression of matrix metalloprotease 13 (MMP13), bone morphogenetic protein-2 (BMP2) and the matrix Gla protein (MGP) were affected during the course of osteoarthritis [14] and IVD aging [15], we were interested in deciphering whether these genes may also be affected by aging in rabbit NP. This evidence concerns the gene BMP2 and osteoarthritis.