GHR and Insulin resistance: Other conditions associated with steatosis are insulin resistance and glucose intolerance.1, 6 On the molecular level, insulin resistance is characterized by defects in IR signaling, which is observed upon the hepatocyte-specific deletion of the GH receptor or STAT5,3, 4 but not upon ablation of hepatic JAK2.16 Insulin resistance might be explained by observations made by others and similarly by us as follows.