SREBF1 and metabolic dysfunction-associated steatotic liver disease: Defects in either of the signaling pathways have been implicated in NAFLD development, including children with NAFLD progressing to end-stage liver disease.10, 11, 21-23 On the molecular level, steatosis is often associated with enhanced expression of the prolipogenic transcription factors, SREBP-1c and PPAR-γ.