Mutations in each of the five subunits of the translation initiation factor eIF2B, including eIF2a encoded by EIF2B1 [Ensembl:ENSCAFG00000007434], can cause leukoencephalopathy with vanishing white matter (VWM, [OMIM:603896]) [17]. This evidence concerns the gene EIF2B1 and Leukoencephalopathy.