Genes which have been associated with brachycephaly on CFA 1 include: THBS2 [Ensembl:ENSCAFG00000000874], which is expressed in bone and cartilage during development and in the adult skeleton [10], and SMOC2 [Ensembl:ENSCAFG00000000868], similar in sequence to BM-40 [Ensembl:ENSCAFG00000017855] which is expressed primarily during embryogenesis and in adult bone tissue [11]. This evidence concerns the gene SPARC and Brachycephaly.