As Bcl-2 could be cleaved by caspases and cleavage of Bcl-2 could further activate downstream caspases [27], [28], and ABT-737 could induce activation of caspases in MM cell lines [29], [30], we examined whether ABT-737 induced Bcl-2 cleavage by a caspase-dependent pathway. Here, BCL2 is linked to Miyoshi myopathy.