Hypercholesterolemic LDLR-/-ApoB100/100 mice with or without type 2 diabetes develop significant coronary artery atherosclerosis with positive arterial remodeling, severe left ventricular dysfunction with regional akinesia distal to coronary stenosis without signs of infarction, and represent preserved but reduced cardiac functional reserve and histological features referring to chronic myocardial hibernation. The gene discussed is LDLR; the disease is type 2 diabetes mellitus.