APOE and Myocardial fibrosis: Lesions in coronary arteries and myocardial fibrosis were described in Western diet fed ApoE-/- mice shortly after the model was generated [29], but since then controversial results have been reported: coronary artery occlusion and subsequent evidence of apical infarction are found by some [30], whereas in other studies the coronary arteries are found to be totally clean [31] or lesions are seen only in proximal parts of the arteries without signs of infracted myocardium [31-33].