Consequently, despite extensive atherosclerosis, lumen areas were not decreased in LDLR-/-ApoB100/100 (690.3 ± 201.2 × 103 μm2) or IGF-II/LDLR-/-ApoB100/100 mice (756.4 ± 149.9 × 103 μm2) compared to non-atherosclerotic C57Bl/6J controls (716.4 ± 112.9 × 103 μm2). Here, IGF2 is linked to atherosclerosis.