We have previously developed a mouse model of diabetic macroangiopathy, where mice overexpressing IGF-II in pancreatic beta cells [19] in hypercholesterolemic LDLR-/-ApoB100/100 background represent hyperglycemia, insulin resistance and mild hyperinsulinemia without concomitant changes in plasma lipid levels [20]. The gene discussed is IGF2; the disease is Hyperglycemia.