Atherosclerosis was associated with compensatory enlargement of the vessel area with a vascular remodeling ratio of 2.63 ± 0.32 in LDLR-/-ApoB100/100 and 2.79 ± 0.28 in IGF-II/LDLR-/-ApoB100/100 mice compared to C57Bl/6J mice (Figure 2C). The gene discussed is IGF2; the disease is atherosclerosis.