ITIH2 and thyroid gland carcinoma: Furthermore, two genes were identified to be regulated in 24 tumor tissues, inter-alpha (globulin) inhibitor H2 (ITIH2), a gene involved in extracellular matrix stabilization and related to prevention of tumor metastasis [27-29] and the functionally undefined gene KIAA0101 which is associated with hepatocellular and thyroid carcinoma [30,31].