The inflamed model established in the experiments may be useful for studying the organ cross-talks for FFA homeostasis and the mechanisms of ectopic lipid deposition induced by chronic systemic inflammation, especially rising from chronic inflammatory diseases characterized by an increased CRP level, as in Crohn's disease [25], autoimmune diseases [26], T2DM, and progressive NAFLD [27]. Here, CRP is linked to type 2 diabetes mellitus.