It has been demonstrated that in both patients and animal models, chronic systemic inflammation characterized by the increase of serum levels of C-reactive protein (CRP) and pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) is closely related the development of NAFLD, insulin resistance and other metabolic disorders [8]. The gene discussed is TNF; the disease is Other metabolic disease.