Our findings illustrate that the exposure of microglial cells to oAβ(1-42) produces the maximal response of TNF-α, PGE2, and nitrite release at 24 h but that of IL-1β at 3 h, which supports that IL-1β is an immediate-response molecule and key immunoregulator at an early AD stage [43-45]. The gene discussed is IL1B; the disease is Alzheimer disease.