More importantly, mice injected with LC-treated DCs and treated with anti-IL-10R antibodies (Figure 5(c), closed circle) exhibited a higher diabetes incidence than mice that were injected with LC-treated DCs and treated with isotype control (Figure 5(c), open circle), indicating that IL-10 production plays an important role in LC-treated DCs-mediated protection. The gene discussed is IL10RA; the disease is diabetes mellitus.