Intraperitoneal injection of a long-lived noncytolytic murine IL-10/Fc fusion protein into young NOD mice prevents insulitis and diabetes by blocking the production of proinflammatory cytokines and IFNγ [57], and IL-10-transduced islet-specific CD4+ T-cells prevent diabetes transfer in NOD mice [58]. The gene discussed is CD4; the disease is diabetes mellitus.