The results of this study showed that the concentration of FBG and FINS in T2DM model rats was significantly higher than normal rats (P < .01), while IAI and the rate of glucose infusion in glucose clamp experiment were significantly lower than normal rats (P < .01), indicating the hyperglycemia of this T2DM model we induced was mainly caused by insulin resistance not by insulin secrete defection; the results confirmed those of previous studies that showed feeding healthy rats with a high-fat diet and injected with low-dose STZ results in insulin resistance and hyperglycemia [27]. The gene discussed is INS; the disease is type 2 diabetes mellitus.