Seizures induced by kainic acid [27] or pilocarpine [28] injection decreased NT-3 expression in the brain of mice, whereas intraventricular infusion of NT-3 in rats inhibited kindling epileptogenesis, mossy fiber sprouting, and increases in hilar area [29], arguing that NT-3 upregulation by forskolin is likely to inhibit seizure development and seizure-related synaptic reorganization. Here, NTF3 is linked to Seizure.