Recently and apart from infection, Gao et al. showed a decrease in classical pro-inflammatory cytokines, including IL-1β and TNF-α, as well as an increase in IL-10 protein levels in the myocardium of MIF-KO versus WT mice (on a C57BL/6 background, male) following 60 min ischemia and 24 h reperfusion [39]. The gene discussed is IL1B; the disease is infection.