For example, the KEGG annotations of one of the clusters (M4) (Table 1) indicated that obesity is a factor that may lead to various cancers (e.g., colorectal cancer and endometrial cancer) and that obesity may also have a relationship with many signalling pathways (e.g., ErbB signalling pathway and Jak-STAT signalling pathway). Here, EGFR is linked to obesity due to melanocortin 4 receptor deficiency.