This issue was addressed in the Scientific Discussion of insulin detemir, published by the EMEA (page 8: "Relative to human insulin, the albumin-corrected mitogenic potency was 9% in CHO-K1 cells, 15% in a human mammary cancer cell line (MCF-7 cells), 11% in a human osteosarcoma cell line, and 25% in L6-IhR cells. Here, INS is linked to breast cancer.