The simulations of succinate dehydrogenase deficiency were very similar to fumarase deficiency in both the reduction in ATP production (Figure 1 and Figure S1, Additional File 5) and the effect of increasing certain metabolite uptake rates (Figure 2 and Figures S2 and S3, Additional File 5). This evidence concerns the gene FH and hyperinsulinemic hypoglycemia, familial, 4.