INS and obesity due to melanocortin 4 receptor deficiency: The difference in body fat distribution between population groups is also worthy of further study, particularly as African subjects have less visceral fat than BMI-matched Europids, and yet are more insulin resistant.77-79 The use of high-throughput gene-screening technology, which has yielded important information on the polygenic nature of obesity via genome-wide association studies132 should therefore be used in African populations to determine the genetic input to adiposity and body fat distribution.