MTHFR and Schnyder corneal dystrophy: In addition, increased prevalence of the FVL mutation in SCT individuals and sickle/β-thalassemia patients was not statistically different from controls (OR=3.84, 95% CI 0.49–29.9, p = 0.19 and OR=3.77, 95% CI 0.31– 45.9, p = 0.29, respectively).9 Also, in a study from Brazil it was suggested that MTHFR C677T might be a risk factor for vascular complications in SCD.44