They concluded that in sub-Saharan African SCD patients FVL is not an additional risk factor for thrombosis.13 Also, In African American with SCD this mutation was uncommon and was not found to be responsible for stroke in these patients.41,42 Further, in the study of Wright et al43 among SCD patients from Jamaica no FVL mutation was found in these patients. Here, F5 is linked to Schnyder corneal dystrophy.