Also, the presence of extensive large vessel thrombosis in a sickle/β0-thalassemia patient from Lebanon doubles heterozygous for FVL and MTHFR C677T (homozygous for FVL and heterozygous for MTHFR has been reported.52 Further, in a sickle cell anemia patient from Israel, Koren et al53 reported the recurrent of cerebrovascular accident and deep venous thrombosis. Here, MTHFR is linked to sickle cell disease.