CTNNA1 and acute myeloid leukemia: Reinduction of CTNNA1 expression led to reduced proliferation, and an increased frequency of apoptosis, suggesting that down-regulation of α-catenin in HSPCs may contribute to transformation of myeloid cells in AML patients with a del(5q).17 However, analysis of mice with a conditional knockout of Ctnna1 in hematopoietic cells (Ctnna1+/−), revealed no defects in hematopoiesis, or predisposition to myeloid neoplasms following mutagenesis with N-ethyl-nitrosourea (ENU).24