DIAPH1 and neoplasm: Diaph1+/− and Diaph1−/− mice have normal hematopoiesis, but develop age-dependent myeloproliferative defects in a small percentage of mice.19 Eisenmann et al., have proposed that mDia1 acts as a node in a tumor-suppressor network that involves multiple 5q gene products (RPS14, EGR1, CTNNA1, and possibly APC).