CTNNA1 and acute myeloid leukemia: Liu et al. showed that the α-catenin gene (CTNNA1) is down-regulated in stem and progenitor cells from MDS and AML patients with a del(5q) as compared to patients lacking del(5q), or normal HSPCs.17CTNNA1 is suppressed due to epigenetic silencing in HL-60 cells, a myeloid leukemia cell line used as a model for del(5q) leukemia.