pII resemble basal-like metaplastic and claudin/occludin-low tumour subtypes, with loss of luminal cell markers (Table 2), that have the propensity for inter-cellular detachment by ‘cadherin switching’ [13], [44] from E-cadherin to N-cadherin, degradation of the basement membrane through the action of various metalloproteinases and molecules listed in Table 3 and establishment of connections with elevated collagen components of the ECM in order to crawl into and through it into the vasculature. The gene discussed is CDH2; the disease is neoplasm.