Finally, to establish that cleaved-CD95L promotes extravasation of activated T-lymphocytes, a process that is instrumental in accumulating T-cells in inflamed tissues and thus in fuelling the inflammatory process, activated T-lymphocytes were incubated either with SLE or healthy sera and both adhesion on and transmigration across endothelial cells were quantified. The gene discussed is FASLG; the disease is systemic lupus erythematosus.